Pre-diabetes | Clinique La Rive

Predisposition

Lifestyle and metabolic factors contribute significantly to the development of prediabetes.

Feeding

A diet high in refined carbohydrates and sugars exacerbates insulin resistance.

Obesity

The accumulation of visceral fat in particular increases metabolic dysfunctions.

Physical inactivity

Sedentary behavior reduces glucose uptake by muscles.

Sleep quality

Poor sleep quality elevates cortisol, which disrupts glucose regulation.

Chronic stress

Prolonged stress triggers hormonal imbalances that affect metabolism.

Symptoms

Prediabetes is often asymptomatic, making regular screening essential.

Fatigue

A sign of glucose misuse.

Darkened Skin

Appears in the neck, armpits or groin as a marker of insulin resistance.

Thirst and increased urination

Subtle signs of a possible increase in blood sugar levels.

Diagnostic

Advances in imaging and biomarker testing allow for earlier and more accurate detection of Alzheimer's disease.

Fasting Blood Sugar

Normal
‍ <60 mg/dL.

Prediabetic
100—125 mg/dL

Hemoglobin A1c

Reflects the average blood sugar level over three months.

Normal
‍ < 5.7%

Prediabetic
5.7% - 6.4%

Oral Glucose Tolerance Test (TTGO)

High glucose levels two hours after ingestion of 75 g of glucose indicate insulin resistance.

Therapy

Reversing insulin resistance requires regular exercise and a low-carb diet to improve glucose uptake, reduce metabolic stress, and extend longevity.

Exercise Zone 2

Regular aerobic activity at moderate intensity helps improve mitochondrial health, glucose uptake, and overall metabolic flexibility.

Caloric restriction

A reduction in calorie intake can decrease insulin resistance and metabolic dysfunction.

Dietary adjustments

A Mediterranean or ketogenic diet can help lower insulin levels and improve glucose metabolism. Reducing refined carbohydrates, added sugars, and alcohol is recommended.

Medications

Metformin: Improves insulin sensitivity and reduces blood sugar by decreasing glucose production by the liver.
GLP-1 receptor agonists: Increase insulin, slow digestion, reduce appetite, and promote weight loss.
SGLT2 Inhibitors: Lower blood sugar by increasing glucose excretion via urine, with heart and kidney benefits.